Job description
Join DxD Hub, a premier initiative within the Agency for Science, Technology and Research (A*STAR) in Singapore, and lead the development of cutting-edge molecular diagnostic solutions. As a Scientist II, you will drive the design, optimization, and validation of robust diagnostic assays that improve patient outcomes. You will work at the intersection of biology, chemistry, and data science, collaborating with cross-functional teams to translate discovery science into deployable, clinically-relevant diagnostics.
In this role, you will contribute to high-impact projects from concept to proof-of-concept, ensuring scientific rigor, reproducibility, and regulatory readiness. You will engage with bioinformatics, translational research, and clinical partners to optimize assay formats, establish performance specifications, and generate data for internal decisions and external collaborations. The position offers a dynamic, collaborative environment with opportunities for leadership, mentorship, and career growth within a world-class research ecosystem.
We are seeking a proactive, results-driven scientist who thrives in a fast-paced setting and is committed to scientific excellence and innovation in molecular diagnostics. If you are passionate about transforming laboratory science into tangible healthcare solutions, DxD Hub could be your next bold career move.
Responsibility
- Lead design, optimization, and validation of molecular diagnostic assays (e.g., PCR/qPCR, isothermal amplification, and sequencing-based panels).
- Develop analytical performance studies, including sensitivity, specificity, accuracy, precision, and robustness assessments.
- Collaborate with bioinformatics, translational research, and clinical teams to interpret results and guide assay development decisions.
- Establish and maintain SOPs, QC procedures, and GLP/GMP-aligned documentation for assay development and validation.
- Plan, execute, and supervise experimental workflows; manage reagents, equipment, and junior scientists on project tasks.
- Prepare technical reports, participate in internal reviews, and present data to multidisciplinary stakeholders and external partners.
- Support technology transfer and regulatory readiness by generating comprehensive data packages and documentation.
Qualification
- Master's or PhD in molecular biology, biochemistry, genetics, bioengineering, or a related field.
- 2+ years of hands-on experience in molecular diagnostics assay development and validation.
- Strong expertise in PCR/qPCR, sequencing-based assays (NGS), and assay optimization.
- Proven experience with analytical method validation, statistical analysis, and quality systems.
- Familiarity with GLP/GMP environments, SOP development, and documentation practices.
- Excellent communication, collaboration, and scientific writing skills; ability to work cross-functionally.
- Flexible, results-driven, and capable of managing multiple projects in a fast-paced setting.